Will Ferrell

Ted (Man with the Yellow Hat) (voice)

Drew Barrymore

Maggie (voice)

David Cross

Junior (voice)

Eugene Levy

Clovis (voice)

Joan Plowright

Ms. Plushbottom (voice)

Dick Van Dyke

Mr. Bloomsberry (voice)

Frank Welker

George (voice)

Ed O'Ross

Ivan (voice)

Michael Sorich

"Seen It" Cab Driver (voice)

Billy West

Manager (voice)